Aerobic radical multifunctionalization of alkenes using tert-butyl nitrite and water
نویسندگان
چکیده
منابع مشابه
Aerobic radical multifunctionalization of alkenes using tert-butyl nitrite and water
Water induces a change in the product of radical multifunctionalization reactions of aliphatic alkenes involving an sp(3) C-H functionalization by an 1,5-hydrogen shift using tert-butyl nitrite and molecular oxygen. The reaction without water, reported previously, gives nitrated γ-lactols, whereas the reaction in the presence of water produces 4-hydroxy-5-nitropentyl nitrate or 4-hydroxy-3-nitr...
متن کاملRegioselective synthesis of nitrosoimidazoheterocycles using tert-butyl nitrite.
A simple and practical method has been developed for the regioselective nitrosylation of imidazopyridines via C(sp(2))-H bond functionalization using tert-butyl nitrite under mild reaction conditions in a short time. A library of 3-nitrosoimidazopyridines with broad functionalities was synthesized in near quantitative yields. The present protocol is also applicable to imidazo[2,1-b]thiazole and...
متن کاملChemoselective nitration of aromatic sulfonamides with tert-butyl nitrite.
A methodology for the efficient conversion of aromatic sulfonamides into their mono-nitro derivatives using tert-butyl nitrite is reported. The reaction exhibits a high degree of chemoselectivity for sulfonamide functionalized aryl systems, even in the presence of other sensitive or potentially reactive functionalities.
متن کاملAerobic palladium-catalyzed dioxygenation of alkenes enabled by catalytic nitrite.
Catalytic nitrite was found to enable carbon-oxygen bond-forming reductive elimination from unstable alkyl palladium intermediates, providing dioxygenated products from alkenes. A variety of functional groups were tolerated, and high yields (up to 94 %) were observed with many substrates, also for a multigram-scale reaction. Nitrogen dioxide, which could form from nitrite under the reaction con...
متن کاملDopaminergic Effects of Isobutyl Nitrite, Isoamyl Nitrite and Butyl Nitrite
Alkyl nitrites have been problematic worldwide due to their recreational use. Although there is a lack of scientific information on their action on the central nervous system (CNS), many anecdotal reports and case studies have inferred the CNS actions of alkyl nitrites. The objective of this study was to investigate the effects of alkyl nitrites on the CNS, especially focusing on the dopaminerg...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Beilstein Journal of Organic Chemistry
سال: 2013
ISSN: 1860-5397
DOI: 10.3762/bjoc.9.196